Epithalamin
Aliases: Epitalamin · Pineal peptide extract
Last verified: 2026-09-23
The short version
A pineal-gland extract — the source of Epitalon; in Russian gerontology studies it normalizes melatonin, reproductive function and reportedly reduces mortality in the elderly. Key fact: Human data are limited: small trials or case-series reports exist, without large randomized studies. Long-term observational series (Khavinson): lower mortality in the elderly; independent confirmation needed. Status: research chemical. Not registered in the West.
Identity & type
- Molecular type
- bioregulator
- Origin
- A pineal-gland extract — the source of Epitalon; in Russian gerontology studies it normalizes melatonin, reproductive function and reportedly reduces mortality in the elderly.
Mechanism of action
Pineal peptides regulate circadian rhythm and the neuroendocrine axis; antioxidant.
not confirmed in humans
Dosing & routes
Official / clinical context
No approved official document exists for Epithalamin. Any protocols mentioned are to be read as information, not as a recommendation.
Regulator-approved labeling and published study designs — never a recommendation.
Community-reported practice
10 mg IM every 3 days, 5 applications per course (Russian protocols). A natural pineal extract (Epitalon's precursor): older patients report better sleep and "rhythm"; data mostly from Khavinson's studies.
Unverified self-reports. Not medical advice. Not endorsement.
Expected effects (community)
A natural pineal extract (Epitalon's precursor): older patients report better sleep and "rhythm"; data mostly from Khavinson's studies.
Protocol — official vs community
Official / label
Russian-approved geriatric peptide preparation (pineal extract): course-based per domestic labeling.
- 01Course-based per domestic labeling
Duration: Course-based.
Not available in US/EU markets; the export gray market sells it as the 'original' to epitalon's 'copy'.
Community (anecdotal)
Mirrors the course structure: daily injections for 10–20 days.
- Cycle:
- 1–2× per year.
- Break:
- Months between courses.
Same evidence caveats as epitalon — same research lineage.
Human evidence
Human data are limited: small trials or case-series reports exist, without large randomized studies. Long-term observational series (Khavinson): lower mortality in the elderly; independent confirmation needed.
Preclinical evidence
Long-term observational series (Khavinson): lower mortality in the elderly; independent confirmation needed.
Known risks
- Rare allergies.characterized
- Unregulated injectable supply — sterility, purity and accurate dose not assuredtheoretical
Teal: characterized in clinical/labeling contexts. Amber: theoretical or reported outside controlled settings.
Unknowns & evidence gaps
- Long-term human safety
- Optimal dose and pharmacokinetics
Frequently asked questions
References
Systematic references are being expanded; verify sources directly before any decision.