Spermidine
Aliases: Spermidine
Last verified: 2026-09-23
The short version
A polyamine from fermented foods (cheese, natto, wheat germ) — an autophagy inducer; epidemiology links intake to longevity; extends lifespan in all model organisms. Status: in clinical trials. Legal supplement.
Identity & type
- Molecular type
- mali molekul
- Origin
- A polyamine from fermented foods (cheese, natto, wheat germ) — an autophagy inducer; epidemiology links intake to longevity; extends lifespan in all model organisms.
Mechanism of action
Autophagy (EP300 inhibition), cardioprotection, anti-inflammatory.
Dosing & routes
Official / clinical context
No approved official document exists for Spermidine. Any protocols mentioned are to be read as information, not as a recommendation.
Regulator-approved labeling and published study designs — never a recommendation.
Community-reported practice
Supplements 1–10 mg/day (trials ~1–3 mg). Subtle: some users report thicker hair and an overall "tone"; epidemiologically strong, subjectively weak effect.
Unverified self-reports. Not medical advice. Not endorsement.
Expected effects (community)
Subtle: some users report thicker hair and an overall "tone"; epidemiologically strong, subjectively weak effect.
Protocol — official vs community
Official / label
Supplement (wheat-germ extract or synthetic). Trials used 0.9–2.4 mg/day.
- 011–2 mg daily
Duration: Continuous.
Autophagy induction is the mechanism; clinical outcome data in humans is pending.
Community (anecdotal)
1–2 mg daily, morning.
- Cycle:
- Continuous.
- Break:
- None.
The 'autophagy' framing makes it a fasting-stack partner in community logic.
Human evidence
SmartAge RCT (cognition): borderline positive; strong epidemiological cohorts.
Preclinical evidence
Preclinical literature preceded the clinical trials; details vary by compound.
Known risks
- Excellent tolerability.characterized
Teal: characterized in clinical/labeling contexts. Amber: theoretical or reported outside controlled settings.
Unknowns & evidence gaps
- Long-term safety in off-label use
Frequently asked questions
References
Systematic references are being expanded; verify sources directly before any decision.