NAD+ Core Stack

Anti-aging

Components

NMN or NRModerate evidence ResveratrolModerate evidence TMG (betaine)

Rationale

The foundational longevity stack: an NAD+ precursor for cellular energetics and sirtuins, resveratrol as a sirtuin "activator", TMG as a methyl donor (offsetting methylation demand at higher NMN/NR doses).

Evidence level

NMN/NR reliably raise NAD+ in humans (multiple RCTs); clinical aging outcomes are modest or neutral. Resveratrol: poor bioavailability, mixed results.

Caution

NMN's regulatory status in the US/EU is contested (not permitted as a supplement); long-term effects of high NAD+ doses in humans are unknown.