Senolytic Cycle (D+Q + Fisetin)

Anti-aging

Components

Dasatinib + QuercetinModerate evidence FisetinModerate evidence

Rationale

Pulsed (not continuous) senolytic use: short courses that clear senescent cells, then weeks/months off. D+Q is the clinical combination; fisetin is the "gentler" natural add-on between cycles.

Evidence level

D+Q: Phase I/II trials (Mayo) — reduced senescence markers, outcomes still under study. Fisetin: preclinical lifespan extension, RCTs ongoing.

Caution

Dasatinib is a serious drug (myelosuppression, pleural effusion) — cycles only under medical supervision; fisetin is safe but unproven in humans.